Drug Design
| Code | School | Level | Credits | Semesters |
| PHAR2030 | Pharmacy | 2 | 20 | Spring UK |
- Code
- PHAR2030
- School
- Pharmacy
- Level
- 2
- Credits
- 20
- Semesters
- Spring UK
Summary
This module provides:
Introduction, development and reinforcement of key concepts relevant to drug design, including principles of molecular recognition, thermodynamics and kinetics, terminology related to the drug discovery pipeline, alternative discovery strategies. Ligand-based drug design: cheminformatics-based approaches, determination of structure-activity relationships. Structure-based design: the determination, prediction, and evaluation of ligand-protein complexes, molecular graphics and computational chemistry.
The prediction and control of ADME properties in drug design.
Target Students
BSc Pharmaceutical Sciences, MSci Pharmaceutical Sciences with a Year in Industry, BSc Pharmacology and Natural Sciences depending on Pathway (Year 2)
Assessment
- 30% Coursework 1: Poster assessment.
- 70% Exam 1 (2-hour): Written exam (in-person)
Assessed by end of spring semester
Educational Aims
The module provides an integrated approach to develop knowledge and understanding, as well as practical and professional transferrable skills, centred on drug design.Knowledge and understanding:The module will provide a grounding in the theory and practice that underpins the modern drug design process.Students will gain knowledge of alternative strategies for drug design, the language/terminology used to describe the processes and molecules involved, and the physics and chemistry behind molecular recognition.They will gain an understanding of the multi-objective optimisation process involved; i.e. the way in which drug design concerns not just target affinity, but also ADME properties, synthetic accessibility, and intellectual property.Professional/practical skills:Students will learn how to use a range of computational and molecular graphics methods for drug design, and for the interpretation and analysis of structure-activity data.Transferable skills:Data analysis methodsProject planningPresentation skillsLearning Outcomes
After successful completion of this module, you should be able to:
A. Knowledge and understanding
A1 Demonstrate a comprehensive understanding of principles relating to the chemical structure, synthesis, analysis and design of medicinal agents
A5 Demonstrate an in-depth knowledge of concepts and analytical methods relevant for drug metabolism and pharmacokinetics
C. Professional/practical skills
C2 Undertake practical experimental work using appropriate materials, operating procedures and instruments;
C3 Undertake numerical tasks and carry out quantitative analysis relevant to pharmaceutical science;
C6 Apply and report scientific knowledge in an ethical manner.
D. Transferable/key skills
D1 Critically use information resources, including library and electronic sources;
D3 Communicate effectively in a variety of forms, including written, verbal and visual.