Advanced Drug Delivery
| Code | School | Level | Credits | Semesters |
| PHAR2029 | Pharmacy | 2 | 20 | Autumn UK |
- Code
- PHAR2029
- School
- Pharmacy
- Level
- 2
- Credits
- 20
- Semesters
- Autumn UK
Summary
This module provides:
Novel materials for drug formulations
Bioelectronic based drugs Design of drug delivery systems
Physiological factors relevant to drug delivery technologies
Modification of drug distribution by formulation.
You will study how novel materials are used for drug formulations and how delivery systems are designed.
The physiological factors which affect particular drug delivery technologies will be discussed.
You will learn how formulation can modify the distribution of a drug in the body and achieve its delivery to the preferred location.
Target Students
BSc Pharmaceutical Sciences and MSci Pharmaceutical Sciences with a Year in Industry and Natural Sciences depending on pathway (Year 2)
Assessment
- 30% Coursework 1: Completion of a workbook assessed after electronic submission.
- 70% Exam 1 (2-hour): Written in person.
Assessed by end of autumn semester
Educational Aims
The module provides an integrated approach to develop knowledge and understanding, as well as practical and professional transferrable skills, centred on advanced drug delivery.Knowledge and understanding:This module reviews approaches to drug formulations based on novel materials and as well as novel delivery system design. It will bring in to play new directions to developing delivery systems for both new chemical entity therapeutics, and critically appraise the use of bioelectronic based therapeutics. The physiological factors which affect particular drug delivery technologies will be discussed in relation to those systems. Formulation technologies based on controlled diffusion of a drug in polymeric material, for example, to achieve a 5-year contraceptive or a 3-month anticancer drug action, will be studied. Approaches to influence normal biodistribution of a drug in the body and achieve its preferential delivery to a diseased site, such as concepts of polymer-drug conjugates or ‘stealth’ nanoparticles in cancer therapy will be introduced.Concepts:Polymers use in drug formulation Depo injectable formulations for modified drug release Biological barriers to distribution in the body in relation to a species size, charge and other physical characteristics. Concepts drug targeting and biological barriers. Physiological drug uptake processes, including cell transport mechanisms, endocytosis, and phagocytosis.Chemical conjugation formulations, including PEGylated and antibody drug conjugatesNano-sized formulations ie ‘nanomedicines’. Merging of electronics with biology.Professional/practical skills:You will learn how to use ChemDraw and apply some basic statistical analysis when analysing data using Excel. This will give you the skill set required to critically appraise data in the context of advanced drug delivery.Transferable skills:You will gain the skills required to write a scientific report including managing long documents and home essential abilities required in the work place such as communication and management skills.Learning Outcomes
After successful completion of this module, you should be able to:
A. Knowledge and understanding
A2 Critically evaluate and apply chemico-physical principles underpinning the design, manufacture, analysis and performance of dosage forms
C. Professional/practical skills
C2 Undertake practical experimental work using appropriate materials, operating procedures and instruments
C3 Undertake numerical tasks and carry out quantitative analysis relevant to pharmaceutical science
C6 Apply and report scientific knowledge in an ethical manner
D. Transferable/key skills
D1 Critically use information resources, including library and electronic sources
D3 Communicate effectively in a variety of forms, including written, verbal and visual.