Angiogenesis and Tumour-Host Interactions
| Code | School | Level | Credits | Semesters |
| ONCG2001 | Cancer and Stem Cells | 2 | 20 | Autumn UK |
- Code
- ONCG2001
- School
- Cancer and Stem Cells
- Level
- 2
- Credits
- 20
- Semesters
- Autumn UK
Summary
This module considers:
• Angiogenesis and the role of angiogenic growth factors
• Angiogenesis in cancers
• Anti-angiogenic cancer therapy
• Regulation of the tumour microenvironment by the lymphatic system
• Introduction to immunology, immunity and the cancer impacted immune system
● The principles of immunotherapy
Target Students
Students studying Cancer Sciences BSc U6UCANCS (B131) and Cancer Sciences MSci U7UCANCSY (B130) and other students with the required pre-requisites including students studying Natural Sciences.
Co-requisites
Modules you must take in the same academic year, or have taken in a previous year, to enrol in this module:
Classes
- One 1-hour workshop
- One 1-hour tutorial
- One 6-hour seminar
- One 5-hour practicum
- One 1-hour lecture each week for 10 weeks
10 lectures; Practical class (wet lab practical class based on an enzyme-linked immunosorbent assay - 5 hours); Group data analysis coursework session and student presentations (6 hours); Open office session (1 hour); Revision workshop (1 hour)
Assessment
- 20% Coursework 1: 1,000 word essay
- 10% Practical 1: Data analysis worksheet linked to the practical component
- 70% Exam 1 (1-hour): MCQ Exam - 1 hour (70%)
Assessed by end of autumn semester
Educational Aims
To consider the process of neoangiogenesis in tumour biology and the approaches that have been used to target this process. To describe in detail the importance of angiogenesis and anti-angiogenic therapy in cancers. To describe in detail the lymphatic system and its involvement in tumour progression. To explore the importance of the tumour microenvironment in tumourigenesis and tumour therapy. To introduce the immune system and the concept of immunotherapy with an emphasis on the treatment of tumours.Learning Outcomes
1. Intellectual skills
Students should be able to demonstrate a good understanding of:
• Angiogenesis and its importance in cancer biology
• Anti-angiogenic cancer therapy
• The tumour microenvironment and the role of immune cells
• The concept of immunotherapy and its application in the treatment of cancers
2. Professional / practical skills
Students should be able to design and perform an enzyme-linked immunosorbent assay and analyse the resulting data.
3. Transferable / key skills
Students should be able:
• Communicate complex written information to a non-specialist audience
• Communicate complex written information in the form of an essay
• Demonstrate self-management and teamworking in the completion of coursework
• Demonstrate problem solving skills and critical thinking as applied to relevant data
• Show basic levels of information technology literacy