Clinical Toxicology
| Code | School | Level | Credits | Semesters |
| MGEM3016 | Medical Sciences and Graduate Entry Medicine | 3 | 10 | Autumn UK |
- Code
- MGEM3016
- School
- Medical Sciences and Graduate Entry Medicine
- Level
- 3
- Credits
- 10
- Semesters
- Autumn UK
Summary
This module will cover the basic principles of toxicology, molecular mechanisms of toxicity and specific organ toxicities. These principles will be reinforced by a number of clinical cases that will cover certain xenobiotics, toxic mechanisms, target organs and toxic outcomes.
Target Students
Students enrolled on Part II of the BSc in Medical Physiology. There are a liminted number of places on this module.
Classes
Delivery via a combination of lectures, tutorials, online recorded lectures and directed readings to provide an approximate content hourage of 22 hours. Activities may take place every teaching week of the Semester or only in specified weeks.
Assessment
- 30% Coursework 1: Web monograph group project
- 70% Coursework 2: An individual task which includes a blog article and an audio-visual presentation and reflective statement on formative feedback.
Assessed by end of autumn semester
Educational Aims
This module serves as a continuation of the pharmacology and overall therapeutic knowledge that the students acquired in Part I. The module aims to provide students a broad overview of the principles of toxicology, by integrating aspects of clinical pharmacology, drug metabolism and pharmacokinetics in a toxicological scenario (toxicokinetics, xenobiotic metabolism). From the basic principles and working with clinical cases and an organ systems approach, the students will be able to acquire the appropriate knowledge and understanding of xenobiotics, cytotoxicity, necrosis and apoptosis, toxicogenomics, toxicological molecular mechanisms (oxidative stress, genotoxicity, carcinogenicity) and specific organ toxicities (liver, kidney, skin, immune, neuro, lung etc).Learning Outcomes
1. Knowledge and understanding. At the end of this module students will be able to:
a. Understand the basic principles of toxicology (xenobiotics, toxic response)
b. Understand and discuss toxicokinetics and toxic outcomes
c. Understand and discuss the importance of genetics, toxicogenomics and outcomes
d. Identify and explain the molecular mechanisms that cause toxicity
e. Identify and explain target organ toxicity
f. Explain main routes and mechanisms of major toxic compounds and their effect in target organs
2. Practical and Professional Skills. At the end of this module students will be able to:
a. Analyse and critique data from toxicological clinical cases and comment on factors such as toxicokinetics, target organ response, etc.
b. Apply toxicokinetics to toxic outcomes
c. Critically evaluate published scientific data regarding the toxicological effect of major xenobiotics
d. Communicate toxicological data accurately and concisely, using different methods of presentation
e. Develop digital competencies via the use of specialist software such as xertes required to build and present an interactive website. Digital competencies will also be developed via the use of search engines to provide suitably researched and referenced material for a website
3. Transferable Skills. Students will also be able to develop a range of transferable skills including:
a. Independent study skills to support life-long learning and professional development
b. Effective communication skills and good interpersonal skills to support work in teams
c. Team work
d. Academic writing skills
e. Oral presenting skills
f. The ability to search for relevant information from the scientific literature for independent, enquiry based learning
g. Understanding of and competency of using digital software for production of an interactive website